The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease
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چکیده
منابع مشابه
The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease
INTRODUCTION Osteoarthritis (OA) is a debilitating disease with poorly defined aetiology. Multiple signals are involved in directing the formation of cartilage during development and the vitamin A derivatives, the retinoids, figure prominently in embryonic cartilage formation. In the present study, we examined the expression of a retinoid-regulated gene in murine models of OA. METHODS Mild an...
متن کاملThe cellular retinoic-acid-binding protein is expressed in tissues associated with retinoic-acid-induced malformations.
Retinoic acid (RA) is thought to play a role in embryonic pattern formation in vertebrates. A naturally occurring gradient of endogenous RA has been demonstrated in the developing chick limb bud, while local application of RA leads to the formation of additional digits. In mammals, a well-defined spectrum of birth defects has been reported as a result of fetal exposure to excess RA. In analogy ...
متن کاملThe cellular retinoic acid binding protein I is dispensable.
The cellular retinoic acid binding proteins I and II (CRABPI and CRABPII) bind retinoic acid with high affinity, exhibit distinct patterns of expression during embryonic development, and are thought to play important roles in the RA signaling pathway. We have generated a targeted mutation of the CRABPI gene using the "hit-and-run" strategy and shown that it prevents the production of a function...
متن کاملThe cellular retinoic acid binding protein II is a positive regulator of retinoic acid signaling in breast cancer cells.
The role of the cellular retinoic acid binding protein type II (CRABPII) in the retinoic acid (RA) signaling pathway is poorly understood. Northern blot analysis of 12 breast cell lines showed that CRABPII mRNA content correlated with growth inhibition by RA, suggesting that this binding protein enhances cellular response to RA. Ectopic CRABPII expression supported dose-dependent growth inhibit...
متن کاملCytosolic retinoic acid binding protein in the human pancreas.
Cytosolic retinoic acid receptor in carcinoma, chronic pancreatitis, and normal pancreatic tissue were examined using sucrose density gradient centrifugation, isoelectric focussing on agarose gel and saturation analysis. Thirteen patients were studied. Cytosolic retinoic acid binding protein (cRABP) was detected in all the samples with chronic pancreatitis and pancreatic carcinoma, but not in t...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2009
ISSN: 1478-6354
DOI: 10.1186/ar2604